| Ctrl+f | Move forward a character |
| Ctrl+b | Move backward a character |
| Ctrl+p | Move to the previous line |
| Ctrl+n | Move to the next line |
| Ctrl+a | Move to the beginning of the current line |
| Ctrl+e | Move to the end of the current line |
| Ctrl+v | Move forward one page |
| Ctrl+y | Move backward one page |
| Ctrl+g | View Pico’s online help |
| Ctrl+x | Exit Pico, saving the file |
| Ctrl+l | Refresh the display |
| Ctrl+w | Search for (where is) text |
| Ctrl+t | Spell check the text |
| Ctrl+j | Format (justify) the current paragraph |
| Ctrl+d | Delete the character at the cursor position |
| Ctrl+^ | Begin selecting text at the cursor.* |
| Ctrl+k | Remove (cut) selected text or current line |
| Ctrl+u | Paste (uncut) last cut text at the cursor position |
| Ctrl+i | Insert a tab at the current cursor position |
| Ctrl+r | Insert (read in) a file at the cursor |
| Ctrl+o | Write (output) the buffer to a file, saving it |